Malarial anaemia and nitric oxide induced megaloblastic anaemia: a review on the causes of malarial anaemia.
نویسنده
چکیده
Direct destruction and ineffective erythropoesis does not adequately explain the cause of anaemia in malaria. It is possible that there are more other mechanisms involved besides the causes described till date in malarial anaemia. The effect of NO on erythropoesis and a major haematological abnormality (microcytic/normocytic/megaloblastic picture) can significantly be observed on repeated exposure. In addition, NO can inhibit the enzyme methionine synthase so functional vit B12 deficiency state may occur which can lead to megaloblastic anaemia. This review will focus on causation of malarial anaemia and nitric oxide induced megaloblastic anaemia.
منابع مشابه
Malaria, Moderate to Severe Anaemia, and Malarial Anaemia in Children at Presentation to Hospital in the Mount Cameroon Area: A Cross-Sectional Study
Background. Malaria remains a major killer of children in Sub-Saharan Africa, while anaemia is a public health problem with significant morbidity and mortality. Examining the factors associated with moderate to severe anaemia (MdSA) and malarial anaemia as well as the haematological characteristics is essential. Methodology. Children (1-14 years) at presentation at the Regional Hospital Annex-B...
متن کاملThe pathophysiology of malarial anaemia: where have all the red cells gone?
Malarial anaemia is an enormous public health problem in endemic areas and occurs predominantly in children in the first 3 years of life. Anaemia is due to both a great increase in clearance of uninfected cells and a failure of an adequate bone marrow response. Odhiambo, Stoute and colleagues show how the age distribution of malarial anaemia and the haemolysis of red blood cells may be linked b...
متن کاملAnaemia and severe malarial anaemia burden in febrile Gabonese children: a nine-year health facility based survey.
INTRODUCTION Anaemia remains a major cause of poor health in children and pregnant women living in sub-Saharan Africa. Malaria is one of the main causes of anaemia in endemic countries. At the time of decreasing Plasmodium falciparum infection prevalence among children, it was essential to analyze the evolution of anaemia and severe malarial anaemia (SMA), the most frequent clinical manifestati...
متن کاملAnaemia and Malaria in Children attending two Sellected Paediatric Clinics in Kano Metropolis, Northern Nigeria
This study was aimed at assessing the extent of correlation between anaemia and malaria amongst paediatric patients attending Paediatric clinics of Murtala Muhammed Specialist Hospital (MMSH), and Hasiya Bayero Paediatric Hospital (HBPH). Two age groups (0-5 and 6-12 years old) were studied (both male and female). Three hundred samples of blood were examined for Malarial Parasites (MP). Two hun...
متن کاملApoptosis of non-parasitised red blood cells in Plasmodium yoelii malaria
Recently, while studying erythrocytic apoptosis during Plasmodium yoelii infection, we observed an increase in the levels of non-parasitised red blood cell (nRBC) apoptosis, which could be related to malarial anaemia. Therefore, in the present study, we attempted to investigate whether nRBC apoptosis is associated with the peripheral RBC count, parasite load or immune response. To this end, BAL...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Journal of vector borne diseases
دوره 46 2 شماره
صفحات -
تاریخ انتشار 2009